The ESFRI Science Clusters, operating as a cluster of clusters in projects like OSCARS and EVERSE, have released the Science Clusters Position Statement on operational commitment to EOSC and Open Research, which articulates the Science Clusters’ vision for the future towards the successful implementation of the EOSC, as the result of five years of collaborative efforts, including interactions with the European Commission, EOSC Association, ESFRI-EOSC task force, and e-Infrastructure Reflection Group (e-IRG).